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Hongfa Zhu, MD, PhD

Subspecialty Interest

Anatomic and Clinical Pathology

Board Certification

Anatomic and Clinical Pathology

Fellowship

Gastrointestinal and Liver Pathology, Beth Israel Medical Center, New York

Residency

Pathology, New York University Medical Center, New York

Medical School

Soochow University School of Medicine, Suzhou, China

Publications, Highlights

  • Antonio Cheesman, Christopher J. DiMaio, Hongfa Zhu, Nikhil A. Kumta, Satish Nagula. EUS-guided microforceps biopsy and needle-based confocal laser endomicroscopy significantly improve the diagnostic yield and have major impact on clinical management of pancreatic cystic lesions. 2019 DDW, Presidential plenary presentation San Diego, CA
  • Chen WC, Warner RRP, Harpaz N, Zhu H, Roayaie S, Kim MK. Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. Pancreas. 2019 Jan;48(1):131-134
  • Christopher J. DiMaio, Xiaoyan Liao, Arnold Szporn, Nikhil A. Kumta, Satish Nagula, Hongfa Zhu. COMBINATION OF NEEDLE-BASED CONFOCAL LASER ENDOMICROSCOPY AND EUS-GUIDED MICROFORCEPS BIOPSY PROVIDES OPTIMAL PATHOLOGIC DIAGNOSIS OF PANCREATIC CYSTIC LESIONS. Gastrointestinal Endoscopy, June 2018Volume 87, Issue 6, Supplement, Page AB434
  • Hongfa Zhu, Sara C. Lewis, Xuchen Zhang, Myron E. Schwartz. Serous Cystic Neoplasms of the Pancreas: Can We Distinguish the So-Called Locally- Aggressive Lesions from the Malignant Lesions? Case Series and Proposal of Unified Term “Serous Cystic Neoplasms of Low Grade Malignant Potential” Medical research archives, 2018
  • Lewis S, Besa C, Wagner M, Jhaveri K, Kihira S, Zhu H, Sadoughi N, Fischer S, Srivastava A, Yee E, Mortele K, Babb J, Thung S, Taouli B. Prediction of the histopathologic findings of intrahepatic cholangiocarcinoma: qualitative and quantitative assessment of diffusion-weighted imaging. Eur Radiol. 2017 Dec 12.
  • Ang C, Stollman A, Zhu H, Sarpel U, Scarborough B, Sahni G, Millis SZ. Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation. Case Rep Oncol. 2017 Jun 22;10(2):548-552.
  • Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same?. Pathol Res Pract. 2017 Aug;213(8):997-1001
  • Bansal A, Thung SN, Zhu H, Schwartz M, Lewis S: Synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma arising in the context of intraductal papillary neoplasms. Clin Imaging. 2016
  • Wang J, Peng L, Zhang R, Zheng Z, Chen C, Cheung KL, Cui M, Bian G, Xu F, Chiang D, Hu Y, Chen Y, Lu G, Yang J, Zhang H, Yang J, Zhu H, Chen SH, Liu K, Zhou MM, Sikora AG, Li L, Jiang B, Xiong H. 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation. Oncotarget. 2016 Mar 24. doi: 10.18632/oncotarget.8344. [Epub ahead of print]
  • Dongwei Zhang, Hongfa Zhu, Noam Harpaz: Overexpression of α1 chain of type XI collagen (COL11A1) aids in the diagnosis of invasive carcinoma in endoscopically removed malignant colorectal polyps. Pathol Res Pract. 2016 Mar 16. pii: S0344-0338(16)30040-1. doi: 10.1016/j.prp.2016.03.005. [Epub ahead of print]
  • Hectors SJ, Wagner M, Besa C, Bane O, Dyvorne HA, Fiel MI, Zhu H, Donovan M, Taouli B. Intravoxel incoherent motion diffusion-weighted imaging of hepatocellular carcinoma: Is there a correlation with flow and perfusion metrics obtained with dynamic contrast-enhanced MRI? J Magn Reson Imaging. 2016 Feb 26. doi: 10.1002/jmri.25194. [Epub ahead of print]
  • Octavia Bane, Cecilia Besa, Mathilde Wagner, Niels Oesingmann, Hongfa Zhu, Maria Isabel Fiel and Bachir Taouli: Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma. Journal of Magnetic Resonance Imaging. Article first published online: 28 SEP 2015 | DOI: 10.1002/jmri.25051
  • Denis Yang, Hongfa Zhu, Christopher DiMaio: “Abdominal Splenosis Mimicking a Liver Mass: Diagnosis by EUS-FNA” Clin Gastroenterol Hepatol. 2015 Jun 29.
  • Hu Y, Zhou J, Ye F, Xiong H, Peng L, Zheng Z, Xu F, Cui M, Wei C, Wang X, Wang Z, Zhu H, Lee P, Zhou M, Jiang B, Zhang DY. BRD4 Inhibitor Inhibits Colorectal Cancer Growth and Metastasis. Int J Mol Sci. 2015:16;16(1):1928-48. doi: 10.3390/ijms16011928. PMID:25603177
  • Agarwal R, Szalkiewicz ER, Warner RR, Roayaie S, Hechtman JF, Zhu H, Kim MK: Multiple endocrine neoplasia type 1 associated with a new mutation in the menin gene and a midgut neuroendocrine tumor. Pancreas. 2014 Jan;43(1):145-6. doi: 10.1097/PMID:24326372
  • Ruane D, Brane L, Reis BS, Cheong C, Poles J, Do Y, Zhu H, Velinzon K, Choi JH, Studt N, Mayer L, Lavelle EC, Steinman RM, Mucida D, Mehandru S.: Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med. 2013 Aug 26; 210(9):1871-88. doi: 10.1084/jem.20122762. Epub 2013 Aug 19. PMID:23960190
  • Hechtman JF, Dimaio CJ, Matloff J, Harpaz N, Zhu H.: Rectal lymphogranuloma venereum mimicking cancer. Endoscopy. 2013 Sep; 45 Suppl 2:E315-6. doi: 10.1055/s-0033-1344407. Epub 2013 Sep 5
  • Yang J, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC 3rd, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation. J Exp Med. 2013 Jul 1;210(7):1447-62. PMID:23797094
  • Hechtman, JF, Franssen, B, Labow, DM, Gordon, RE, DiMaio, CJ, Wilck, EJ, Carrasco-Avino, G, Zhu, H. Intraductal Polypoid Lipid-Rich Neuroendocrine Tumor of the Pancreas: Report of a Rare, Clinically Challenging Diagnosis. Endocr Pathol. 2013 Mar;24(1):30-5. doi: 10.1007/s12022-012-9231-x. PMID:23315081
  • Zhu, H, Obeidat, K, Ouyang, J, Zhang, X, Roayaie, S, Schwartz, M, Thung, S. Recurrent Giant Hemangiomas of Liver after Resection: Report of Two Cases with Literature Review. World J Gastrointest Surg. 2012 Nov 27;4(11):262-6
  • Ungaro, R, Babyatsky, MW, Zhu, H, Freed, JS. Protein-Losing Enteropathy in Ulcerative Colitis, Case Rep Gastroenterol. 2012 Jan;6(1):177-82
  • Lewis JR, Itzkowitz S, Zhu H, Ward SC, Anandasabapathy S. Sequential downgrading of dysplasia in ulcerative colitis using carbon dioxide-based cryotherapy. Endoscopy. 2012;44(S 02):E96-E97
  • Zhu, H, Qin, L, Zhong, MH, Gordon, R, Raofi, M, Hechtman, J, Schwartz, M, Roayaie, S, Klimstra, D. Carcinoma ex Microcystic Adenoma of the Pancreas: A Report of a Novel Form of Malignancy in Serous Neoplasms, Am J Surg Pathol, 2012; 36:305-310
  • Recavarren C, Zhang LJ, Labow DM, Wong M, Liang J, Zhu H, Wang JH, Xu RL. The Histology and Clinical Significance of Pancreatic Intraepithelial Neoplasia (PanIN) differ with Associated PancreaticLesions. Hum Pathol. 2011 Jan;42(1):18-24
  • Zhu, H, Sun, K, Ward S. C, Schwartz M, Thung S.N, Qin L. Primary Hepatic Signet Ring Cell Neuroendocrine Tumor: A Case Report with Literature Review. Semin Liver Dis. 2010 Nov;30(4):422-8. Epub 2010 Oct 19.
  • Zhu H, Bodenheimer, jr HC, Clain DJ, Min AD, Theise ND. Hepatic lipogranulomas in chronic liver disease: associations with hepatitis C and fatty liver disease. World J Gastroenterol. 2010 Oct 28;16(40):5065-9..
  • Teitelbaum EN, Nguyen SQ, Zhu H, Salky BA. Laparoscopic resection of a schwannoma of the ascending colon. Am Surg. 2010 Jul;76(7):E97-9
  • Fitzhugh VA, Kim SA, Borcich A, Zhu H, Wu M, Szporn AH, Chen H.Metastatic hepatocellular carcinoma presenting as a pancreatic mass by computed tomography scan and mimicking a primary neuroendocrine tumor: A potential pitfall in aspiration cytology (p NA), Diagn cytopathol, July 2009 (Epub ahead of print)
  • Glazer E, Golla V, Forman R, Zhu H, Levi G, Bodenheimer HC Jr. Serrated adenoma is a risk factor for subsequent adenomatous polyps. Dig Dis Sci. 2008 ;53(8):2204-7.
    Liu HY, Zheng G, Zhu H, Woldegiorgis G. Hormonal and nutritional regulation of muscle carnitine palmitoyltransferase I gene expression in vivo. Arch Biochem Biophys. 2007 Sep 15;465(2):437-42.
    Kang SH, Perle MA, Nonaka D, Zhu H, Chan W, Yang GC.. Primary Ewing sarcoma/PNET of the kidney: Fine-needle aspiration, histology, and dual color break apart FISH Assay, Diagn cytopathol, 2007, 35(6): 353-7
  • Shim K, Zhu H, Westfield LA, Sadler JE. A recombinant murine meizothrombin precursor, prothrombin R157A/ R268A, inhibits thrombosis in a model of acute carotid artery injury. Blood. 2004; 15:415-9.
  • Zhu H, Shi J, Treber M, Dai J, Arvidson DN, Woldegiorgis G. Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding. Arch Biochem Biophys. 2003; 413:67-74
  • Dai J, Zhu H, Woldegiorgis G. Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. Biochem Biophys Res Commun. 2003; 301:758-63.
  • Dai J, Zhu H, Shi J, Woldegiorgis G. Identification by mutagenesis of conserved arginine and tryptophan residues in rat liver carnitine palmitoyltransferase I important for catalytic activity. J Biol Chem. 2000; 275:22020-4.
  • Woldegiorgis G, Shi J, Zhu H, Arvidson DN. Functional characterization of mammalian mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris. J Nutr. 2000; 130(2S Suppl):310S-314S.
  • Shi J, Zhu H, Arvidson DN, Woldegiorgis G. The first 28 N-terminal amino acid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl CoA sensitivity and high-affinity binding. Biochemistry. 2000; 39:712-7.
  • Shi J, Zhu H, Arvidson DN, Woldegiorgis G. A single amino acid change (substitution of glutamate 3 with alanine) in the N-terminal region of rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA inhibition and high affinity binding. J Biol Chem. 1999; 274:9421-6.
  • Shi J, Zhu H, Arvidson DN, Cregg JM, Woldegiorgis G. Deletion of the conserved first 18 N-terminal amino acid residues in rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA sensitivity and binding. Biochemistry. 1998; 37:11033-8.
  • Zhu H, Shi J, Cregg JM, Woldegiorgis G. Reconstitution of highly expressed human heart muscle carnitine palmitoyltransferase I. Biochem Biophys Res Commun. 1997; 239:498-502.
  • Zhu H, Shi J, de Vries Y, Arvidson DN, Cregg JM, Woldegiorgis G. Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I. Arch Biochem Biophys. 1997; 347:53-61.
  • Sun X, Zhang X, Liu W, Zhu H. Molecular cloning of cDNA encoding mitochondrial very-long-chain acyl-CoA dehydrogenase from bovine heart. Acta Pharmacol. Sin. 1997; 18: 25-32.
  • Zhu H, Guo S, and Yin Q. Effect of hypothalamic arcuate nucleus stimulation on nociceptive response of the spinal horn neurons in rats. Chin. J. Physiol. 1991; 7: 222-229.

Awards and Honors

Cao Zongxian, MD, PhD

Hongfa Zhu, MD, PhD

  • Pre-doctoral fellowship, Medical College of Ohio at Toledo, Dept of Pharmacology, 1991 – 1995
  • Junior Pathology Faculty Recognition Award by Residents, June 4, 2015, Mount Sinai Medical Center, Department of Pathology

Affiliate Medical Centers & Resources